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Phenotypic characteristics of hairy cell leukaemia

It has a characteristic morphology and immunophenotypic profile. It is important to distinguish HCL from other B cell lymphoproliferative disorders due to availability of different chemotherapeutic agents. This study presents clinical, haematological and immunophenotypic profile of patients with HCL seen over a period of four years in a tertiary care hospital in north India. Methods: Twenty one cases of hairy cell leukaemia were analyzed for their clinical details, haemogram, bone marrow examination and immunophenotypic findings. Results: Age of the patients ranged from yr with male predominance. Weakness and fever were commonest presentations.
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Hairy Cell Leukemia (HCL)

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Hairy cell leukemia: a histo-cytochemical and ultra-structural study

Ann Clin Case Rep. Hairy cell leukemia is a rare B cell lymphoproliferative disorder. Patients typically present with peripheral cytopenias, circulating leukemia cells, marked splenomegaly and marrow infiltration. We describe a case of a 68 year old man who presented solely with psychiatric symptoms of delusions, without the classical features of cytopenias or splenomegaly.
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It is characterized by pancytopenia, splenomegaly, bone marrow fibrosis, and presence of atypical lymphoid cells with hairy projections in peripheral blood, bone marrow and spleen. HCL is potentially curable and treatment with purine analog cladribine induces complete remission CR. The clinical features, laboratory parameters, bone marrow findings, cytochemistry, immunophenotyping, and outcome with treatment were studied. Results: Among 8 cases of HCL who were treated with cladribine, 7 achieved remission and 1 succumbed to infection during course of treatment.
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